Professor Ian Meyers is a general dental practitioner in Brisbane, and an honorary professor at The University of Queensland School of Dentistry. He has over forty years of combined experience in dental research and education, and with clinical dentistry in private practice, university clinics and hospital based dental clinics. He is a past President of the Royal Australasian College of Dental Surgeons and the Queensland Branch of the Australian Dental Association. He is President-Elect of the Australasian section of the International College of Dentists, and a Fellow of the Academy of Dentistry International and Pierre Fauchard Academy.
In 2017 he received the Order of Australia Medal for services to dentistry, professional associations, and tertiary education. Professor Meyers has extensive experience in comprehensive patient care, with special interests in diagnosis and management of the worn dentition, geriatric and aged care dentistry, adhesive restorative dental materials, fibre-reinforced composites, and the management of patients through minimum intervention dentistry

Modern dental restorative materials, combined with enhanced clinical techniques, can provide highly aesthetic and high strength restorations for both anterior and posterior teeth. Appropriate case selection and optimized clinical techniques can ensure the restorations last well and can be maintained long term for the benefit of the patient. Fibre reinforced restorative materials and high strength composite resins have a multitude of uses in restorative dentistry, and they greatly enhance the options available for strengthening weakened and endodontically treated teeth.
Short fibre reinforced composites (SFRC) provide an ideal material for reinforcing teeth due to their extremely high fracture toughness which is known to be the best indicator of longevity of a restoration. These materials can be utilized for both direct and indirect restorations and enhance the outcomes from both functional and aesthetic aspects. This presentation will review a range of restorative materials and techniques and through a series of clinical cases demonstrate how they can be utilised successfully in daily clinical practice.

Professor Hien Chi Ngo is a distinguished dental professional with extensive expertise in clinical practice, research, and education. Throughout his career, he has actively treated advanced cases of caries and erosion while focusing his research on dental materials and cariology. His work emphasizes the clinical management of caries in elderly and medically compromised patients, as well as the interactions between glass-ionomers, the oral environment, and silver diamine fluoride.

As an educator, Professor Ngo has published and lectured extensively on dental materials, Minimal Intervention Dentistry, and clinical cariology. He has served on the editorial boards of multiple dental journals and regularly contributes to international conferences. His leadership extends across six dental schools on three continents, where he has held deanships and directorships, including in the UAE and Western Australia.

Professor Ngo’s contributions to dentistry have earned him global recognition, with accolades from the Minister of Health in Vietnam and the International College of Dentists. Additionally, he has served as a technical consultant to several dental organizations and co-invented multiple dental products, significantly advancing the field of dental care.

Despite continuing major advances in dental materials and techniques. The average longevity of a direct tooth coloured restoration is still hovering around 10 years. Restorative materials are still poor substitute for natural tooth structure. Teeth can withstand high mastication load because they are built using two very different materials, so it has been suggested that we should also replicate this design when rebuilding a tooth. Today, technological innovations have provided dental professionals with new tools and science has provided us with many possible ways of handling the above issues. This lecture aims at identifying important factors that govern clinical success, reviewing possible solutions and demonstrating practical ways at preserving and restoring tooth structure. Topics covered include:
1. Understanding the role of Glass Ionomer Cements in restorative dentistry
2. How to maximise the clinical performance of Glass Ionomer Cements and Composite Resin
3. Conservative restorative techniques, alternative options for restoration, and maintaining restored dentitions
4. Understanding appropriate materials selection and gaining maximum benefits

Dr. Ho Thi Hoa graduated as a Doctor of Odonto-stomatology from Faculty of Odonto-stomatology, University of Medicine and Pharmacy at Ho Chi Minh city in 2017. In the period between 2017 and 2020, she studied and graduated degree of Master, Specialist level I as well as Resident Doctor from Faculty of Odonto-stomatology, University of Medicine and Pharmacy at Ho Chi Minh city.
From 2021 to now, she has been a lecturer in Periodontology Department, Facuty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh city.

Topical hyaluronic acid (HA) has been considered as an adjuvant agent for periodontitis (PD).
Objectives: This study aimed to evalute effect of hyaluronic acid on proliferation, migration of human gingival fibroblasts and assess the clinical effects of subgingival application of 0.2% HA gel, following scaling and root planning (SRP) in PD patients.
Methods: We evaluated the viability of gingival fibroblasts in HA medium, selected the optimal concentration and tested proliferation by counting cell numbers and cell migration by scratch test. In clinical randomized split-mouth study, 733 periodontal pockets of 28 patients with PD were investigated. They were divided into control and experimental groups. The experimental group received subgingival administration of 1 ml 0.2% HA gel into each pocket immediately after SRP, and then after 1 week, 2 weeks, and 3 weeks. Clinical parameters and subgingival plaque were assessed at baseline and 6 weeks after SRP. Quantitative real-time polymerase chain reaction for Porphyromonas gingivalis (Pg), Treponema denticola (Td), Fusobacterium nucleatum (Fn), and Tannerella forsythia (Tf) were also performed.
Results: HA give positive effect on proliferation, migration of human gingival fibroblasts. After 6 weeks, there were significant decreases in clinical parameters, and the number of Fn in the experimental group compared to the control group (p < 0.05). The number of Pg, Td, and Tf decreased significantly in both groups, with no significant difference between the 2 cohorts (p > 0.05).
Conclusions: The topical application of HA gel in periodontal pockets after SRP may have a beneficial effect in PD patients. This additional treatment appears to help reducing 2 types of bacteria (Tf and Fn) better than non-surgical treatment only.

– Lecturer, Department of Prosthodontics, UMP- HCMC

2010: Doctor of Dental Surgery (DDS), UMP-HCMC
2014: Degree of Dental Residency, UMP-HCMC
2018-2019: Participant in The International Postgraduate Program: Advanced Clinical Training in Implant Dentistry, Showa University, Japan
2020: Certificate of Suction-effective mandibular complete denture by Japan Plate Denture Association.
2020: DIU certification by the Aix-Marseille II University, France

Ms. Lu Lam Thien graduated Doctor of Dental Surgery (DDS), UMP-HCMC on 2010, attained Dental Residency from UMP-HCMC on 2014. Participated in The International Postgraduate Program: Advanced Clinical Training in Implant Dentistry, Showa University, Japan. She is currently the lecturer of Department of Prosthodontics, UMP- HCMC since 2015. Doctoral Researcher since 2021.

Residual ridge resorption (RRR) after tooth extraction is a complex process with significant individual variation. Excessive bone loss can complicate restorative treatment, and genetic factors may play a role. Objectives: This study aimed to investigate the association between three single nucleotide polymorphisms (SNPs) in genes involved in bone remodeling (RANKL, RANK, and OPG) and the presence of severely resorbed edentulous mandibular ridges in a Vietnamese population.

Methods: 100 completely edentulous mandibles were recruited. Bone height was measured using standardized protocols. Saliva samples were collected for DNA extraction and analysis of the three SNPs. Genotype and allele frequencies were compared between patients with severe RRR and controls.

Results:The mean bone height was significantly lower in the RRR group (13.31 ± 2.5 mm) compared to the control group (24.56 ± 5.2 mm). An association was found between the rs9533156 SNP in RANKL and RRR risk. Individuals carrying the T allele had a two-fold lower risk of RRR (OR = 2.1). Conversely, the CC genotype in the rs1805034 SNP of RANK was three times more frequent in the RRR group (OR = 2.86). The rs2073618 SNP in OPG did not show a significant association with RRR.

Conclusions:These findings suggest that genetic variations in bone remodeling genes may influence susceptibility to RRR in Vietnamese individuals. This knowledge could potentially inform the development of genetic tests to identify those at higher risk and guide personalized treatment strategies.

Keywords: SNP, Bone remodelling, Residual ridge resorption.

2003: Graduated as a Doctor of Odonto-Stomatology at the Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at HCM City.
2004: Trained in General Odonto-Stomatology in University of Bordeaux, France.
2009-2011: Master of Medicine, Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at HCM City.
2018-2023: PhD in Medicine, Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at HCM City.
Since 2012, lecturer Department of Operative dentistry and Endodontics, University of Medicine and Pharmacy at HCM City.
Since 2020, Person in charge in Unit of Preclinical simulation practice, Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at HCM City.

Objectives: This study aimed to assess the efficacy of Calcium silicate biomaterials as direct pulp capping agents, particularly in relation to mineralized tissue formation observed on cone-beam computed tomography (CBCT).
Methods: The study employed a randomized controlled clinical trial design with a half-mouth research model involving on permanent premolars planned for orthodontic extraction in under 30-year-old patients. Clinical symptoms such as pain, pulp sensitivity tests, and radiological parameters were documented. Radiographic assessment criteria involved the measurement of root dentin thickness, continuity of dentinal bridge, and the presence of periapical lesions on CBCT. Statistical analysis was performed using SPSS 20.0, with a threshold p value of ≤ 0.05 signifying statistical significance of the results.
Results: There was no discernible disparity between the two groups in terms of average thickness and dentinal bridge continuity before and after extraction (p>0.05). Notably, about 40% of cases exhibited the absence of dentin bridge, and there were no signs of inflammation, pulp necrosis and periapical lesions post-treatment.
Conclusion: The study findings indicate the favorable efficacy of biomaterials in direct pulp capping therapy and its potential in preserving the pulp. Additionally, CBCT radiographs proved to be an effective modality for early detection of dentinal bridge formation, signifying reparative hard tissue manifestations.
Key words: Direct pulp capping, Calcium silicate Biomaterials, Mineral Trioxide Aggregate (MTA), Biodentine.

Dr. Kieu Quoc Thoai graduated as a Doctor of Dental Surgery at at the Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City in 2017. He received his PhD degree and completed postgraduate training programs in Endodontics at Tokyo Medical and Dental University, Japan in 2022. He is a lecturer at the Department of Pediatric Dentistry – Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City. He focuses on research on regenerative endodontics, the role of immune cells in the healing process of pulp tissue, and the application of digital dentistry in restorative pediatric dentistry.

Regenerative endodontics (REPs) is a biologically based procedures designed to replace damaged dental pulp structures of immature permanent teeth diagnosed with pulp necrosis. The ultimate goal of REP is to regenerate the damaged pulp-dentin complex, reestablishing a functional pulp tissue. Since the first clinical case of regenerative endodontics was reported in 2001, many studies from basic biology to clinical trials have been performed, providing more scientific basis for getting closer to the goal of regenerating the dentin-pulp complex. Currently, Key concepts of REPs includes Revasculization Endodontics, Cell-homing Regenerative Endodontics and Cell-based Regenerative endodontics. However, only Revasculization Endodontics has been widely applied in clinical practice, when the regenerated tissue in the root canal has histological characteristics similar to periodontal and bone tissue. Cell-homing and Cell-based Regenerative endondontics methods are being studied in animal models and a few clinical trials. In this article, we will update the latest scientific research results related to Cell-homing and Cell-based Regenerative endodontics and a vision of applying these methods to clinical application in the future.

Graduated Bachelor of Dental Science (BDSc) from University of Queensland with First Class Honours and the Carlisle C. Bastian prize for Operative Dentistry in 1982. He also held PhD in Operative Dentistry from Federal University of Santa Catarina in Brazil, and PhD in Medical Sciences (Cariology) – Radboud University Medical Center Nijmegen in The Netherlands. He is working as an Associate Professor of Operative Dentistry, Department of Dentistry, School of Health Sciences, and the Coordinator of the Graduate Program in Dentistry (MSc and PhD), School of Health Sciences at University of Brasília in Brazil.
Prof. Hilgert has lectured in numerous congresses, universities and continuing education activities in Brazil and abroad. Recent lectures include Brazilian Society of Dental Research (SBPqO), Brazilian Society of Esthetic Dentistry, International Congress of São Paulo, Revista Clínica Congress, Brazilian Group of Operative Dentistry Professors, Universidad de Chihuahua (Mexico), University of Iowa (USA), Charité-Berlin (Germany), Portuguese Society of Stomatology and Dental Medicine (Portugal), Minimally Invasive Esthetic Dentistry Congress (Lithuania), Interdental Online World Congress (Germany), among others.

The resin infiltration technique is an effective microinvasive approach to halt the progression of non-cavitated proximal carious lesions. Understanding the rationale of the technique and employing it on well indicated cases can avoid many class II restorations, complying with the pillars of Minimal Intervention Dentistry. Also, smooth surfaces with esthetic concerns due carious white spot lesions, cases of mild to moderate fluorosis and other enamel developmental defects opacities can be treated by infiltrating resin into the de/hypo-mineralized enamel.
Resin infiltration for esthetic purposes can be integrated with other therapies as tooth bleaching and minimally invasive composite restorations to solve a myriad of clinical situations. This lecture intends to summarize the available evidence on resin infiltration, as well as to share more than a decade of clinical experience using the resin infiltration techniqueintends to summarize the available evidence on resin infiltration, as well as to share more than a decade of clinical experience using the resin infiltration technique.

Dr. Chia Tze Kao has held various prestigious positions in the field of dentistry and orthodontics. He served as Vice President of Chung Shan Medical University from 2017 to 2020 and was the Dean of its College of Oral Medicine from 2012 to 2016. Between 2009 and 2011, he chaired the Institute of School of Dentist at the same university. Dr. Kao was 10th President of the Taiwan Association of Orthodontists from 2007 to 2008 and Chief of the Taiwan Board Orthodontist of the Taiwan Health Department from 2009 to 2010. Since 2011, he has been the Chief of the Test Committee of Orthodontic Examination at the Ministry of Examination. He has been the Editor for the Journal of Dental Science since 2008 and will serve as Chief Editor of the Asia Pacific Dental Journal starting in 2024. Dr. Kao is also a committee member for several Taiwan government departments and holds memberships in international orthodontic organizations.

The mandible completes its growth and development the slowest among the facial bones. Therefore, when skeletal malocclusion occurs, the mandible plays an important role in the overall diagnosis and treatment plan. However, does undergoing orthodontic treatment after the completion of growth guarantee success? Clinically, relapse often occurs post-orthodontic treatment, and these issues are frequently observed in the mandibular dentition or in changes in the size and position of the mandible. This indicates that the mandible is a “troublemaker.”
The causes of mandibular overgrowth or undergrowth are influenced by genetic or environmental factors. Genetically, it is well-known that intervention should not occur too early in the treatment process, making the differential diagnosis of mandibular abnormalities very important. Regarding environmental factors, patients may have neuromuscular abnormalities, oral habits, or temporomandibular joint injuries from childhood, affecting normal mandibular development. Therefore, predicting mandibular growth abnormalities requires comprehensive evaluation and consideration to ensure effective treatment. In this presentation, we will share cases to illustrate the changes in the mandible and occlusion during long-term follow-up after orthodontic and occlusal treatment under different scenarios. It is hoped that this will help everyone think of the best treatment methods in clinical practice.

Dr. Tran Thi My Hanh graduated with a Doctor of Dental Surgery degree in 2000, a Master’s degree in 2006, and a Ph.D. in 2013 from Hanoi Medical University. She has participated in numerous specialized training courses in minimally invasive dentistry, cosmetic dentistry, and orthodontics. Currently, she is the Deputy Head of the Pediatric Dentistry Department at the School of Dentistry and a member of the International Association of Pediatric Dentistry (IAPD). She has published over 50 articles in the field and is the chief editor of the “Clinical Handbook of Pediatric Dentistry.” Additionally, she has contributed to the compilation of Pediatric dentistry textbooks for both undergraduate and postgraduate students.

Although primary teeth are only present in the mouth for a limited time, they have many important functions: chewing, speech, aesthetics, space maintenance for permanent teeth, and stimulating jawbone development. For primary teeth with extensive tissue loss, in order to ensure their longevity until natural exfoliation and to perform their functions well, preformed crowns are necessary to restore the tooth structure. However, for primary teeth with severe hard tissue loss, where restoring the tooth structure with preformed crowns is not feasible, dentists must decide whether to preserve the tooth or extract it. In this presentation, a dentist with 20 years of experience in pediatric dentistry practice and teaching, treating thousands of young patients each year, will share her insights on this crucial decision.

Dr. Deepesh earned his BDS from Bharati Vidyapeeth Dental College and Hospital, Pune, in 2009, followed by a Master’s in Pedodontics & Preventive Dentistry from the prestigious MCODS, Manipal. He is renowned for his numerous international and national publications, including innovative contributions like Rashmdeep’s method for diagnosing mouth breathers, Rashmdeep’s abscess in mixed dentition, and the NIMS modification of band and loop. He has contributed to three chapters in Dr. Shobha Tandon’s iconic textbook “Pediatric Dentistry.” His expertise extends to oral parafunctional habits in children, such as mouth breathing and incorrect tongue posture, and he focuses on early-stage malocclusion treatments with minimal appliances. Dr. Deepesh emphasizes a collaborative approach, working with medical colleagues to address children’s sleep issues. He runs three airway-based pediatric dental practices in Jaipur under the name Breathe Right Dental Clinic and heads a social project that maintains an online directory of India’s pediatric dentists. His dedication to innovative pediatric dental care has significantly impacted the field.

In this presentation, I will share my experience and protocols developed over a decade in exclusive pediatric dental practice, focusing on the crucial topic of etiology and anticipation of malocclusion in pediatric patients. We will not only explore the underlying causes of malocclusion, key considerations when screening pediatric patients to anticipate malocclusion development, we will also see the significant roles that breathing patterns, tongue posture, and swallowing habits play in jaw development. Furthermore, I will discuss strategies for building a collaborative team of professionals dedicated to improving children’s quality of life by optimizing their ability to breathe, eat, and sleep effectively. Join me in this informative session to gain insights into enhancing pediatric dental care and promoting overall well-being in young patients.

Associate Professor. Nguyen Thi Kim Anh graduated doctor of dental surgery and resident doctor degrees at University of Medicine and Pharmacy at Ho Chi Minh City in 1990 and 1994. She attended a refresher course at Tokyo Medical University, Japan for a year from 1996. She received her PhD degree at University of Medicine and Pharmacy at Ho Chi Minh City and the title of Associate Professor in the year 2007 and 2013, respectively. In the period between 1996 and 2023, she was a lecturer of Basic Dentistry department of the University of Medicine and Pharmacy at Ho Chi Minh City. She assumed chairman position of the scientific council – Odonto Stomatology department – University of Medicine and Pharmacy at Ho Chi Minh City from 2019 to 2023 May and assistant dean of Odonto- Stomatology department – Van Lang University from 2023 June to 2024 May as well.
Her field of research is about: Characteristics of occlusion, TMJ, resolving, and treating mastication system dysfunction include muscle pain, occlusion, TMD…

“Comprehensive dental care” is a philosophy in which the dentist practices examination and treatment centered around the patient, allowing the patient to participate in the treatment process and providing numerous benefits. Disorders or pathologies of the masticatory system, such as malocclusion, muscle pain, temporomandibular joint pain, and aesthetic-functional issues in occlusal rehabilitation, all require a comprehensive treatment plan based on accurate diagnosis through thorough information gathering during examination.
To successfully implement comprehensive dental care, it is essential to conduct a comprehensive examination of the masticatory system at each patient appointment.
The content of the lecture includes:
1. Components of comprehensive examination of the masticatory system
2. Signs and symptoms of malocclusion
3. Screening questions to detect “issues” in the masticatory system

Dr. Huynh Cong Nhat Nam graduated DDS degree from University of Medicine and Pharmacy at HCM city in 2010. He received PhD degree from Chulalongkorn University (Thailand) in 2016. He accomplished the postdoc program in University of Tokyo (Japan) in the period between 2018 and 2021. From that time on, he works as a researcher as well as a lecturer in University of Medicine and Pharmacy at Ho Chi Minh city.

The prevalence of oral cavity squamous cell carcinoma (OSCC) has an upward trend. To enhance early detection and improve prognostic assessments, this study harnesses the power of machine learning (ML) to dissect and interpret complex patterns within mRNA-sequencing data and clinical-histopathological features.
Firstly, the RNA extraction process was optimized and the library was prepared to increase the amount of useful data obtained from the low-quality RNA formalin-fixed paraffin-embedded (FFPE) oral cancer tissue samples on 20 samples with rRNA Depletion or Exome capture-based methods, to make recommendations on metrics such as RNA input output concentrations and obtain full RNA sequencing data for downstream bioinformatics analysis. Secondly, 100 optimized RNAseq samples were clustered and classified by different ML models using 22 clinical and histopathological features.
Results showed Exome capture-based methods’ RNA sequencing library preparation process outperformed rRNA Depletion methods in both library output concentration and RNA sequencing data in bioinformatics analysis. RNAseq samples were divided into 2 groups with different gene expressions, clinical and histopathological patterns. ML models could predict these classes with accuracy > 70% and suggested new bio markers.
To conclude, Exome capture-based methods are an advantageous procedure in the preparation of libraries for RNA sequencing from low-quality tissue samples such as FFPE. The study helps to contribute to the insight of tumor microenvironment of OSCC and provide the accuracy ML model for bio markers prediction using only clinical and histopathological features.

Lecturer – Department of Periodontology, Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh city.
2006-2012: University of Medicine and Pharmacy at Ho Chi Minh city, Vietnam
Faculty of Odonto-Stomatology
Awarded DDS Degree
2013-2018: Chulalongkorn University, Bangkok, Thailand
Faculty of Dentistry
Awarded PhD in Oral Biology Degree
2019-Present: University of Medicine and Pharmacy at Ho Chi Minh city, Vietnam
Faculty of Odonto-Stomatology. Department of Periodontology.
Researchs in progress:
-Role of nutrients in prevention and treatment of periodontal diseases.
– Immunology and Microbiology in periodontal health.
– Adjuntive therapies in treatment of periodontal diseases.
– Applying of digital in periodontal treatments.

According to the S3 Level Clinical Practice Guideline (CPG) for the treatment of Stage I–III periodontitis, the second step of therapy (cause-related therapy) is aimed at controlling (reducing/eliminating) the subgingival biofilm and calculus (subgingival instrumentation). In addition to this, the following interventions may be included:
•Use of adjunctive biological, physical or chemical agents: Platelet-rich fibrin, probiotics, laser, enamel matrix derivative,…
•Use of adjunctive host-modulating agents (local or systemic): vitamin D, vitamin C, anti-inflamatory drugs, …
•Use of adjunctive subgingival locally delivered or systemic antimicrobials
This presentaiton aim to summarize the latest clinical and scientific evidences supported the impact of the adjuncts to periodontal therapy, as well as the future direction of applying these therapies into conventional non-surgical and surgical periodontal treatments.

Dr. Tran Yen Nga completed her DDS at the Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City, from 1987 to 1993. She then undertook a residency in the Department of Periodontology at the same institution from 1993 to 1996. In 2021, Dr. Nga earned her PhD from the Faculty of Odonto-Stomatology. Since 1998, she has served as a lecturer in the Department of Periodontology at the University of Medicine and Pharmacy at Ho Chi Minh City.

The objective of this study was to compare the efficacy of 810nm diode laser and surgical scapel technique in gingival physiologic melanin hyperpigmentation treatment. Total 26 arch of 16 patients with bilateral physiologic melanin hyperpigmentation were recruited in this study. Contralateral quadrants were randomly assigned to receive 810nm diode laser (test group) or scapel technique (control group). Clinically meaningful postoperative (PO) pain was assessed at follow-up interviews 1, 7 days after surgery by using Visual Analogue Scale. The intensity of gingival pigmentation was recorded by using DOPI (Dummett oral pigmentation index) at baseline, 1 month, and 3 month PO. Wilcoxon signed-rank test and Mann-Whitney U test were applied to analyze these data. Postoperative intensity of pain was mild to average, the side treated by scapel technique showed higher pain score but no significant difference was observed between two techniques (p>0.05). At 1 month and 3 months PO, the intensity of gingival pigmentation in both laser and scapel groups decreased significantly compared to baseline (p<0.00). However, no statistically significant difference was observed in terms of PODI between two groups at both two -time points PO (p>0.05). The 810nm diode laser and scapel technique have similar efficacy in gingival depigmentation treatment.

Dr. Mai Hai Yen obtained a DDS – Diplôme d’Etat de docteur en chirurgie dentaire- Doctor of Dental Surgery from the University of Nantes in the French Republic in 2013. Following this, she pursued a Certification in Odonto-stomatology Orientation at the School of Dentistry, Hanoi Medical University from 2014 to 2015. Subsequently, she served as a residential practitioner in the High-tech healthcare center of Odonto-Stomatology and also worked as an assistant lecturer in the Prosthodontic department at the School of Dentistry, Hanoi Medical University from 2016 to 2018. Lastly, Dr Mai completed her Master of Science and Doctor of Philosophy in Dentistry, specializing in Conservative Dentistry & Prosthodontics, at Kyungpook National University in South Korea from 2019 to 2022.
Her research interest is: “Digital technologies have revolutionized the way Healthcare professionals provide patient care. There also no exception in Dentistry. Indeed, digital dentistry has allowed for greater precision, accuracy, and efficiency, while also improving patient outcomes.”

The use of intraoral optical scans has increased in daily clinical practice. Directly digitized anatomic structures of oral cavity reduce clinical and laboratory steps that were previously required for analog impressions, such as selecting the impression tray, preparing the impression material, and pouring a stone model. Moreover, the digital impression can increase patient convenience by eliminating allergic reactions to the impression material and possible contact between the impression tray and intraoral tissues. The accuracy of intraoral scans is essential when applying a complete digital workflow for dental prosthetic treatment. Previous studies reported that scan strategy and movement of the scanner tip while scanning affected the quality and reliability of the scanned image.
The effect of scan strategy on the accuracy of scanning is more significant in comprehensive full dental arch scans because the possible error in image stitching is proportionately increased as the scan size is increased. Scan strategies during intraoral scanning have been of an increasing interest, but optimal scan motions or scan paths are still controversial in the literature.
The purpose of this presentation is to investigate the accuracy of full-arch intraoral scans obtained by various scan strategies as an optimal proposition for effective clinical practice.

Dr. Vikas Aggarwal, an alumnus of Government Dental College, Patiala, has over 25 years of private practice experience. His dedication has earned him fellowships from FPFA, FICD, FWCOI, and FBADI.
Dr. Aggarwal is the first in Asia to achieve DTR certification (TMJ treatment with Disclusion Time Reduction). He runs TMJA Harmony and CLINIC VIVA, specializing in TMJ disorders, and serves as a Key Opinion Leader for Tekscan and Bioresearch Inc. USA.
A renowned speaker, he trains dentists on TMD/occlusion internationally and serves as the Asian Advisor for the College of Oral Implantology & Tissue Regeneration Asia. He is also the National Coordinator for the Global Academy of TMJA Harmony.
Dr. Vikas brings extensive knowledge and experience through his International Center of Dental Excellence, known as I-CODE, in Delhi NCR. The center offers advanced clinical trainings and hands-on courses on the latest techniques, taught by internationally acclaimed clinicians.

Obstructive sleep apnea, Bruxism, and Temporomandibular disorder (TMD) are encountered in dental offices in routine practice. Poor quality of sleep, pain and discomfort of jaws affects the quality of life of the patients, with the right understanding of correlation and differential diagnosis of bruxism, OSA, TMD, the oral appliances can be used very effectively in management of these problems which badly affects the quality of life of the patients.

Dr. Vikas Aggarwal, an alumnus of Government Dental College, Patiala, has over 25 years of private practice experience. His dedication has earned him fellowships from FPFA, FICD, FWCOI, and FBADI.
Dr. Aggarwal is the first in Asia to achieve DTR certification (TMJ treatment with Disclusion Time Reduction). He runs TMJA Harmony and CLINIC VIVA, specializing in TMJ disorders, and serves as a Key Opinion Leader for Tekscan and Bioresearch Inc. USA.
A renowned speaker, he trains dentists on TMD/occlusion internationally and serves as the Asian Advisor for the College of Oral Implantology & Tissue Regeneration Asia. He is also the National Coordinator for the Global Academy of TMJA Harmony.
Dr. Vikas brings extensive knowledge and experience through his International Center of Dental Excellence, known as I-CODE, in Delhi NCR. The center offers advanced clinical trainings and hands-on courses on the latest techniques, taught by internationally acclaimed clinicians.

Obstructive sleep apnea, Bruxism, and Temporomandibular disorder (TMD) are encountered in dental offices in routine practice. Poor quality of sleep, pain and discomfort of jaws affects the quality of life of the patients, with the right understanding of correlation and differential diagnosis of bruxism, OSA, TMD, the oral appliances can be used very effectively in management of these problems which badly affects the quality of life of the patients.

Professor Junji Tagami graduated from Tokyo Medical and Dental University (TMDU), achieving his DDS in 1980 and his PhD in 1984. He was appointed to the Professor and Chair of Cariology and Operative Dentistry, Graduate School at TMDU in 1995. He is a Professor Emeritus at TMDU, and Visiting Professor at the Faculty of Dentistry, Chulalongkorn University. He continues clinical, academic and educational activities as the director of Aoyama Quartz Dental Clinic.
He is a prolific author who has contributed more than 500 papers to peer-reviewed international journals and some 200 papers to Japanese academic journals in the fields of cariology, tooth-colored dental restorative systems, the bonding of materials to dental tissues. His research on the mechanism and structure of caries is believed to be one of the most important background for achieving minimally invasive dentistry utilizing adhesive materials. The development of the Optical Coherent Tomography (OCT) for dental diagnosis and application for laboratory material testing is one of his outstanding achievements in the recent years.
Because of his contribution in dental research and education, he was awarded Honorary Degrees from King’s College of London and Mihidol University in Thailand, the distinguished scientist award, Wilmer Souder Award, from IADR, and The President’s Award of Japanese Association of Dental Science.

Direct composite resin restoration is becoming one of the best choices as the esthetic restorations varying from traditional small cavity restorations to the endo-crown. Even the direct bridge restoration is reported to exhibit excellent clinical performance. The direct esthetic restoration is achieved by excellent adhesive technology and color matching of the composite resins. Bonding performance of the recent adhesive resin was extremely improved even with simplified bond procedures. Single step adhesive material without light irradiation can provides us the reliable bonding.
The Supra-Nano sized filler particle provides the excellent light transmittance and diffusion effects. Because of this unique technology, the so called “Auto-color matching” is achieved even with the filling of single shade composite. At the same time the Supra-Nano sized filler particle provides the excellent long-lasting surface gloss showing the “self-shining effect”. A particular size of the spherical filler was found to show the unique photonic characteristic of the so called “structural color effect”. This technology is utilized in the recent composite resin for restorations. Thanks to these excellent technologies, the esthetic restorations with the direct composite resin are becoming very much simplified with excellent results. The long term clinical performances of composite restorations and new applications will be demonstrated and discussed.

Professor Junji Tagami graduated from Tokyo Medical and Dental University (TMDU), achieving his DDS in 1980 and his PhD in 1984. He was appointed to the Professor and Chair of Cariology and Operative Dentistry, Graduate School at TMDU in 1995. He is a Professor Emeritus at TMDU, and Visiting Professor at the Faculty of Dentistry, Chulalongkorn University. He continues clinical, academic and educational activities as the director of Aoyama Quartz Dental Clinic.
He is a prolific author who has contributed more than 500 papers to peer-reviewed international journals and some 200 papers to Japanese academic journals in the fields of cariology, tooth-colored dental restorative systems, the bonding of materials to dental tissues. His research on the mechanism and structure of caries is believed to be one of the most important background for achieving minimally invasive dentistry utilizing adhesive materials. The development of the Optical Coherent Tomography (OCT) for dental diagnosis and application for laboratory material testing is one of his outstanding achievements in the recent years.
Because of his contribution in dental research and education, he was awarded Honorary Degrees from King’s College of London and Mihidol University in Thailand, the distinguished scientist award, Wilmer Souder Award, from IADR, and The President’s Award of Japanese Association of Dental Science.

Direct composite resin restoration is becoming one of the best choices as the esthetic restorations varying from traditional small cavity restorations to the endo-crown. Even the direct bridge restoration is reported to exhibit excellent clinical performance. The direct esthetic restoration is achieved by excellent adhesive technology and color matching of the composite resins. Bonding performance of the recent adhesive resin was extremely improved even with simplified bond procedures. Single step adhesive material without light irradiation can provides us the reliable bonding.
The Supra-Nano sized filler particle provides the excellent light transmittance and diffusion effects. Because of this unique technology, the so called “Auto-color matching” is achieved even with the filling of single shade composite. At the same time the Supra-Nano sized filler particle provides the excellent long-lasting surface gloss showing the “self-shining effect”. A particular size of the spherical filler was found to show the unique photonic characteristic of the so called “structural color effect”. This technology is utilized in the recent composite resin for restorations. Thanks to these excellent technologies, the esthetic restorations with the direct composite resin are becoming very much simplified with excellent results. The long term clinical performances of composite restorations and new applications will be demonstrated and discussed.

PhD. Nguyen Thi Bich Ngoc completed her DDS at Hanoi Medical University, Vietnam, in 1998 and subsequently participated in the Hospital Resident Physician Program at the same institution in 2003. She earned her PhD from the School of Dentistry at Hanoi Medical University in 2014. She also undertook an AusAID Australian Leadership Award Fellowship with the Hoc Mai Australia Vietnam Medical Foundation from July to September 2012.
PhD Ngoc’s experience in orthodontics includes serving as a Resident in Orthodontics at Hanoi Medical University from 1999 to 2002, a Lecturer in the Orthodontics Department at the School of Dentistry from 2003 to 2009, and continuing as a Lecturer in the Orthodontic Department at School of Dentistry, Hanoi Medical University from 2009 to the present. Since 2018, she has been Vice Head of the Orthodontic Department at the School of Dentistry, Hanoi Medical University. She is an active member of the Vietnam Association of Orthodontists (VAO), the World Federation of Orthodontists (WFO), and the American Association of Orthodontists (AAO).

Treatment of skeletal Class III malocclusion has always been a challenging issue for clinicians, especially when the malocclusion foundation is due to skeletal factors in patients who have completed growth. Treating these patients often requires a combination of orthodontics and orthognathic surgery to achieve the best results. However, surgery is often denied by patients due to the complications during and after the procedure as well as the high treatment fee. The innovation of temporary anchorage devices has expanded the scope of tooth movement and met patient needs. In this presentation, I would like to share my experience on the most effective non-surgical treatment option for patients with skeletal Class III malocclusion.

Prof. Trinh Dinh Hai, PhD, DDS graduated from Hanoi Medical University in 1983, received Master’s degree in 1996, and PhD in 2001. He assumed many important positions for 27 years from 1995, for example, Vice Director of National Hospital of Odonto- Stomatogy (NHOS) (1995 – 2006); Director of NHOS (2006 – 2019); Vice director of Vietnam University Odonto-stomatology (2003 – 2009); Vice dean of School of Dentistry- Hanoi Medical University (2009 – 2019); Head of Department of Dentistry, VNU (2016 – 2022) and former president of Vietnam Odonto-stomatology Association as well.
Prof. Trinh Dinh Hai is currently woking as Dean of Faculty of Dentistry, University of Medicine and Pharmacy which is a member of Vietnam National University. On a side note, he is a vice president of Vietnam Medical Association.

In over past two decades along with the development of socio-economy in Vietnam, there were many factors related to dental caries in children. Positive factors included activities communicating dental prevention, school dental program, dental services, fluoride products…. Risk factors for dental caries included increasing sugar consumption, lower fluoride concentration in drinking water…. So, the research on dental caries in Vietnamese children in the past decades is very important to provide useful information for the prevention program in the whole country.
The results show that primary caries experience in the 6 – 8 years old children increased both in the proportion and indices of dmft, dmfs. This indicated that caries risk factors for the primary dentition of children is high. Regarding to the permanent dentition, caries experiences in 12 years old children decreased both in the proportion and indices of DMFT, DMFS. This indicated that the school-based dental program is effective in prevention.
The above mentioned results show that preschool children in Vietnam need to be cared and prevented dental caries like primary school children.

Dr. Nguyen Hong Nhung graduated in 2010 at Moscow Medical Academy. She graduated with a specialization in Plastic Surgery in 2011 at Hanoi Medical University. She graduated from Advanced Microsurgery course at Kuala Lumpur Hospital in 2015. She completed Ph.D in 2022 at the Institute of Clinical Medical Research 108. Her researches in the fields of maxillofacial surgery, plastic surgery and microsurgery. Dr. Nguyen Hong Nhung is a member of the International Association of Maxillofacial and Plastic Surgery. Dr. Nguyen Hong Nhung is working at University of Medicine & Pharmacy – Vietnam National University, Hanoi.

According to the World Association for Cancer Prevention, oral cavity cancer ranks 6th in the most common cancers. In the United States each year there are more than 30,000 new cases, of which about 7,000 people die from oral cancer. In 2018, worldwide, more than 117,000 people died from oral cancer. The survival rate of oral cavity cancer has barely changed over the past 30 years, even though medicine is still evolving, showing how dangerous this disease is. Symptoms of head and neck cancer are often non-specific, patients come for examination and treatment when they are in the late stages. Therefore, it is necessary to have a good surgical plan to thoroughly treat the pathology, and at the same time not affect the patient’s quality of life. After surgical resection often leaves large defects . We has successfully using free flaps for reconstruction large defects in the maxillofacial region. The most used flaps were fibula flap, anterolateral femoral flap and lateral arm flap which have been used flexibly in maxillofacial reconstruction. The results of patient treatment are radical and improve the quality of life of the patients.

Dr. Ta Anh Tuan graduated doctor of dental surgery degree at Hanoi Medical University in 2008. He held degree of master in dentistry here 4 years later. From that time on, he has been a lecturer in the Department of Implantology and the Department of Oral and Maxillofacial Surgery – School of Dentistry, Hanoi Medical University. Besides, he is a surgeon in Oral and Maxillofacial surgery Department, Hanoi Medical University Hospital.

This report describes the digital fabrication of a surgical obturator (SO) using a patient’s computed tomography (CT) data from tumor area. This procedure has some differences from conventional method which includes making an impression and obtaining a patient cast prior to surgery to allow for SO fabrication. The present approach allows for a virtual resection based on the patient’s CT images as well as the intraoral scanner; the SO is digitally designed with animation software and fabricated by 3D printing. The SO is relined with a denture reliner at the time of surgery to complete the obturation of the maxillectomy defect.

Doctor Nguyen Truong Minh graduated from Hanoi Medical Universtiy in 2010. He got his Master of Science from Mahidol University, Thailand in 2015. He has trained in oral maxillofacial surgery and got fellowship in craniofacial surgery at Chang Gung Memorial Hospital, Taiwan.
His practice focuses on oral and maxillofacial surgery especially orthognathic surgery. He has attended many trainings course update in orthognathic surgery in Korea, Thailand, Taiwan, etc. He has had some presentations in some international conferences and publish some international papers about orthognathic surgery.
He is currently a lecturer in Oral and Maxillofacial surgery department, School of Dentistry, Hanoi Medical University. He is also a main surgeon in orthognathic surgery team, Oral and Maxillofacial surgery Department, Hanoi Medical University Hospital.

Introduction: The purpose of this study is to evaluate the hard and soft tissue characteristics of patients with class III malocclusion who treated with surgery first orthognathic approach on 3D computed tomography.

Methods: Research on 3-dimensional computed tomography of 36 patients with skeletal class III malocclusion who were examined and treated by surgery first orthognathic approach at Hanoi Medical University Hospital from December 2019 to December 2023.
Results: In the study group, there were 16 female patients (44,4 %), 22 patients were male (55,6 %). Regarding hard tissue, the study patient group had an average N-Me distance of 123,55±4,32mm, an average NA-APg angle of -6.47±5.49°, SNA= 81,26±5,33 (°), SNB= 85,61±4,23 (°), ANB= -3,87±2,21 (°). Upper incisors angle relative to the skull base (ISN) was 114,32±6,87 (°). The lower incisor angle to the mandibular plane was 83,39±7,82 (°). Regarding soft tissue, the patient group had an average nasolabial angle of 111,34±12,06 (°), an average mentolabial angle of 149,38±15,21 (°), 21 patients had deviations of the soft tissue Menton point (Me) to the midsagittal plane greater than 3mm, accounting for 58.97%.

Conclusion: Patients with class III skeletal malocclusion who are treated by surgery first orthognathic approach have a concave face, the maxilla is retrude, and the mandible is protrude compared to the skull base. There is compensation of the teeth, the upper incisors were proclined and the lower incisors were retroclined. Patients have obtuse nasolabial and mentolabial angles. The majority of patients studied had facial asymmetry.

Keywords: Orthognathic surgery, surgery first approach, class III malocclusion, 3D computed tomography

Dr. Nguyen An Nghia studied doctor of dental surgery program at Hanoi Medical University from 2001 to 2007. In the year 2011, he received resident surgeon and master of oral and maxillofacial surgery degrees at Hanoi Medical University. Since 2017 September, he has been a Ph.D. candidate as well as research assistant at Biomedical Engineering Department, National Chengkung University, Taiwan. In addition, he has been a surgeon in the Department of Oral and Maxillofacial Surgery, Hanoi Medical University Hospital; Maxillofacial Trauma Department at the National Hospital of Odonto and Stomatology Hanoi since 2011. Besides, he is a lecturer in the Department of Implantology, School of Dentistry, Hanoi Medical University.

Our primary focus in this study was directed towards the advancement of a ceramic composite coated with a polymer, intended for effective delivery of antimicrobial drugs. To achieve this, we employed a method known as micro-arc oxidation (MAO), which enabled the creation of a porous structure comprised of calcium acetate hydrate (Ca(CH3COO)2•H2O) and sodium phosphate monobasic monohydrate (NaH2PO4•H2O). The purpose of this structure was to enhance the biocompatibility of titanium, a material commonly used in various orthopedic implants. A spray coating technique was utilized to load an aqueous drug onto the porous surface. Subsequently, we employed a layer-by-layer spin coating approach to apply gamma polyglutamic acid (γ-PGA), a widely recognized naturally occurring hydrophilic biodegradable polymer.
The comprehensive findings derived from this study highlight the promising potential of employing a porous structure in conjunction with γ-PGA as an effective, economically viable formulation for localized, continuous, and controlled drug delivery. Notably, the antimicrobial efficacy of the antibiotic was not compromised upon its incorporation into the porous structure, as evidenced by the inhibition of E. coli growth. With the retained drug activity, this drug delivery system based on the porous structure holds significant promise for a wide range of applications in the fields of tissue engineering and pharmaceutical science.

Dr. Nguyen Thi Thu Huong graduated with a Doctor of Dental Surgery from Hanoi Medical University in 2005 and completed her residency training at the same university in 2010. She is currently pursuing her PhD at Hanoi Medical University, with her research topic titled “Abnormalities in Dentofacial Features and Genetic Types in Patients with Cleft Lip and Palate”. Dr. Hương is also a lecturer in the Department of Prosthodontics at the Faculty of Dentistry, Hanoi Medical University. Her research focuses on dentofacial characteristics and genetic types in patients with cleft lip and palate.
Dr. Nguyen Minh Duc holds a Doctor of Dental Medicine degree from Hanoi Medical University, having graduated in 2018. He subsequently earned a PhD from Aichi Gakuin University in Japan, where his research focused on comprehensive treatment for cleft lip and palate patients. Dr. Duc has published several articles in reputable journals on genetics and speech and language therapy.

This study examined dental and craniofacial features in 98 children with Osteogenesis Imperfecta (OI). Dentinogenesis Imperfecta (DI) affected 45.9% of OI patients, more severely in primary teeth, notably lower incisors. High rates of Class III malocclusion, open bite, and crossbite were prevalent. Taurodontism occurred in 41.4% of OI cases, significantly higher than controls. Tooth eruption was normal, and there was no increased incidence of dental caries or gingivitis. Impacted maxillary second molars were found in 30.8%, and tooth agenesis in 5.9%. Facial anomalies included a triangular face (12%) and frontal bossing (10%). Genetic analysis of 31 OI patients revealed variants predominantly in COL1A1 and COL1A2 (86.5%), with higher severity linked to COL1A1 mutations. Qualitative variants affecting collagen structure correlated with more severe OI and DI, whereas quantitative variants reducing collagen production were less severe. Glycine substitutions strongly associated with DI, and qualitative variants showed higher rates of Class III malocclusion. Taurodontism rates were similar between COL1A1 and COL1A2 variants. These findings highlight the genetic basis and varied clinical manifestations of OI, emphasizing the impact of specific collagen gene mutations on dental and skeletal features.

Dr. Nguyen Minh Duc holds a Doctor of Dental Medicine degree from Hanoi Medical University, having graduated in 2018. He subsequently earned a PhD from Aichi Gakuin University in Japan, where his research focused on comprehensive treatment for cleft lip and palate patients. Dr. Duc has published several articles in reputable journals on genetics and speech and language therapy.

Aims: Dozens of causative genes and their mechanisms of nonsyndromic cleft lip with or without cleft palate (NSCL/P) were revealed through genome-wide association and linkage studies. Results were, however, not always replicated in differentpopulations or methodologies. This study used case–control and family based approaches to investigate the etiology of NSCL/P and its two subtypes: nonsyndromiccleft lip only (NSCLO) and nonsyndromic cleft lip and palate (NSCLP) among theVietnamese population.
Methods: Two hundred and seventeen NSCL/P case-parent trios (one affected child and two parents), including 105 NSCLO and 112 NSCLP were involved for a familybased design; and 273 ethnic and region-matched healthy controls with no cleft history in their families were recruited for a case–control design. Three SNPs consisting of TFAP2A (rs1675414 and rs303048) and 8q24 (rs987525) were genotyped using the TaqMan SNP genotyping assay.
Results: TFAP2A rs1675414 was associated with NSCLO, replicated by both case-control and family based tests. Other SNPs yielded no evidence of susceptibility to NSCL/P or two subtypes.
Conclusion: The current investigation suggests an intriguing role of TFAP2A in the etiology of NSCLO among the Vietnamese population.
Keywords: cleft and palate, TFAP2A.

Dr. Nguyen Viet Anh earned his Doctor of Dental Surgery degree from Hanoi Medical University in 2015. He subsequently completed both a three-year residency and a two-year master’s program at the same institution in 2018. Currently, he is pursuing a doctoral fellowship at Hanoi Medical University, focusing his research on zirconia laminate veneers. Dr. Viet Anh has authored multiple international publications exploring zirconia surface preparation and manufacturing techniques.

Aims: The improvement of computer-aided design and computer-aided manufacturing (CAD/CAM) has changed the methods of fabricating laminate veneers. The objectives of this study were to evaluate the marginal and internal fit of ceramic veneers manufactured with different CAD/CAM techniques. Methods: A metal die was made by copying a prepared plastic maxillary central right incisor and scanned for designing a laminate veneer. One hundred laminate veneers were made with four different CAD/CAM techniques (n=25), including milled lithium disilicate (MLD), heat-pressed lithium disilicate with 3-dimensional (3D) printed wax patterns (PLD), milled zirconia (MZ), and 3D-printed zirconia (PZ). The virtual marginal and internal fit of fabricated veneers was evaluated with digital crown fitting software. The actual marginal and internal fit was measured with the silicone replica method under a digital microscope. The measured data were analyzed using the one-way analysis of variance and the Turkey test. Results: There were significant differences in marginal and internal fit (P < 0.001) among manufacturing techniques. Both the virtual and actual marginal and internal gaps were higher in the PLD and PZ groups compared to the MLD and MZ groups. Conclusion: All four CAD/CAM techniques of manufacturing veneers, that is, milled lithium disilicate, heat-pressed lithium disilicate with 3D-printed wax patterns, milled zirconia, and 3D-printed zirconia, have clinically acceptable marginal and internal fit. Milled zirconia and lithium disilicate veneers demonstrated superior marginal and internal fit compared to 3D-printed zirconia and heat-pressed lithium disilicate veneers with 3D-printed wax patterns.
Keywords: Ceramic laminate veneers, silicone replica, marginal fit, zirconia, lithium disilicate

Duong Duc Long, D.D.S., Ph.D, works as a lecturer in the Department of Dental Public Health at the School of Dentistry, Hanoi Medical University. He graduated as a Doctor of Medicine, Stomatology Specialist at National Kharkiv Medical University, Ukraine (2012), and received PhD degree at National Cheng Kung University, Taiwan (2021)
He is also a Research fellow of the Department of Dental Biomaterial, Okayama University, Japan (2016) and became an Honorary Member of The Phi Tau Phi Scholastic Honor Society of the ROC (Taiwan) in 2022.

Dental caries has been considered the heaviest worldwide oral health burden affecting a significant proportion of the population. Therefore, an appropriate and accurate early detection method is demanded to prevent dental caries. This study aims to develop a two-stage computational system that can detect early caries from smartphone color images: in the first stage, carious lesion areas were identified and extracted from sound tooth regions. Then five characteristic features of these areas were intendedly selected and calculated to give as input into the classification stage, where five classifiers (Support Vector Machine, Random Forests, K-Nearest Neighbors, Gradient boosted tree, Logistic Regression) were evaluated to determine the best one among them. On a set of 620 smartphone images of unrestored extracted teeth, our system achieved accuracy, sensitivity, and specificity that were 87.39%, 89.88%, and 68.86% in the detection stage. For the classification stage, the Support Vector Machine model was recorded as the best model with accuracy, sensitivity, and specificity were 88.76%, 92.31%, and 85.21%. While the proposed system needs to employ and validate with more realistic data, its potential as a non-invasive, inexpensive diagnostic tool with high accuracy in clinical settings is promising.

The field of interest of the Maekawa lies at the host-microbe interface at mucosal surfaces and mechanisms of microbial dysbiosis and inflammation. More recently, Maekawa has identified key molecules involved in the homeostasis of the periodontium and other host tissues. The combination of basic scientific and translational research has led to innovative approaches to clinical problems, such as exemplified by periodontal disease. He has identified DEL-1 as a local gatekeeper of inflammatory cell recruitment by restraining β2 integrin-dependent inflammatory cell adhesion to the endothelium in various tissues, including the periodontium. Accordingly, recombinant DEL-1 was shown to protect against experimental periodontitis and multiple sclerosis in appropriate animal models. DEL-1 has moreover associated naturally occurring chronic periodontitis in old mice.
[Selected Publications: First or Corresponding author only] 1. A novel macrolide-Del-1 axis to regenerate bone in old age. iScience, 2024
2. ERM inhibits neutrophilic inflammation and mucosal disease by DEL-1. JCI Insight, 2020
3. The secreted protein DEL-1 activates a β3 integrin-FAK-ERK1/2-RUNX2 pathway and promotes osteogenic differentiation and bone regeneration. J Biol Chem, 2020
4. DHEA Inhibits Leukocyte Recruitment through Regulation of the Integrin Antagonist DEL-1. J Immunol, 2020
5. Secreted Del-1 regulates myelopoiesis in the hematopoietic stem cell niche. J Clin Invest, 2017
6. Inhibition of natural periodontitis in non-human primates by inhibitor of C3. J Clin Periodontol, 2016
7. DEL-1 restrains osteoclastogenesis and inhibits bone loss in nonhuman primates. Sci Transl Med, 2015
8. Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β-C/EBPβ pathway. Nat Commun, 2015

The aging of the oral cavity is accompanied by a loss of flexibility and regenerative capacity. The integrin-binding secreted protein DEL-1 is involved in the regulation of both the initiation and resolution of inflammation in different diseases. Recently, we demonstrated that the anti-inflammatory action of erythromycin (ERM) is mediated through the upregulation of DEL-1. Induced DEL-1 can promote alveolar bone regeneration during the resolution of experimental periodontitis. DEL-1 also regulates osteoclastogenesis and decreases inflammatory bone resorption. Although DEL-1 promotes resolution of inflammation and removal of senescent cells, its expression declines with aging, and it has been shown to lose flexibility for tissue repair and regeneration. However, increased expression of DEL-1 by ERM was observed not only in young mice but also in old mice (77w old). Normally, regeneration is challenging in aging mice, but erythromycin induces DEL-1, which can lead to bone regeneration and it works as senolytic compound. These findings suggest that the ERM-DEL-1 axis may be therapeutically exploited to restore bone loss due to periodontitis and aging.

Professor Hien Chi Ngo is a distinguished dental professional with extensive expertise in clinical practice, research, and education. Throughout his career, he has actively treated advanced cases of caries and erosion while focusing his research on dental materials and cariology. His work emphasizes the clinical management of caries in elderly and medically compromised patients, as well as the interactions between glass-ionomers, the oral environment, and silver diamine fluoride.

As an educator, Professor Ngo has published and lectured extensively on dental materials, Minimal Intervention Dentistry, and clinical cariology. He has served on the editorial boards of multiple dental journals and regularly contributes to international conferences. His leadership extends across six dental schools on three continents, where he has held deanships and directorships, including in the UAE and Western Australia.

Professor Ngo’s contributions to dentistry have earned him global recognition, with accolades from the Minister of Health in Vietnam and the International College of Dentists. Additionally, he has served as a technical consultant to several dental organizations and co-invented multiple dental products, significantly advancing the field of dental care.

Despite continuing major advances in dental materials and techniques. The average longevity of a direct tooth coloured restoration is still hovering around 10 years. Restorative materials are still poor substitute for natural tooth structure. Teeth can withstand high mastication load because they are built using two very different materials, so it has been suggested that we should also replicate this design when rebuilding a tooth. Today, technological innovations have provided dental professionals with new tools and science has provided us with many possible ways of handling the above issues. This lecture aims at identifying important factors that govern clinical success, reviewing possible solutions and demonstrating practical ways at preserving and restoring tooth structure. Topics covered include:
1. Understanding the role of Glass Ionomer Cements in restorative dentistry
2. How to maximise the clinical performance of Glass Ionomer Cements and Composite Resin
3. Conservative restorative techniques, alternative options for restoration, and maintaining restored dentitions
4. Understanding appropriate materials selection and gaining maximum benefits